Sr Bioinformatics Scientist Job at Twist Bioscience, South San Francisco, CA

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  • Twist Bioscience
  • South San Francisco, CA

Job Description

Twist Bioscience seeks a Senior Bioinformatics Scientist to develop computational methods and predictive models supporting DNA synthesis and protein characterization work. The role involves algorithm development, NGS data analysis, statistical modeling, and collaboration with experimental scientists to guide product development.

Responsibilities

  • Develop computational methods and algorithms for DNA synthesis, sequence analysis, and protein characterization
  • Partner with experimental scientists to design experiments and interpret results guiding product development
  • Analyze NGS and experimental datasets to identify patterns, variability, and unexpected outcomes
  • Apply statistical methods and machine learning to connect sequence features with product quality and performance
  • Build and validate reproducible analysis pipelines using Nextflow supporting research workflows

Requirements

  • Ph.D. with 3+ years, Master's with 6+ years, or Bachelor's with 8+ years in bioinformatics, computational biology, or related field
  • Strong Python programming and experience analyzing biological or experimental data
  • Hands-on NGS analysis experience and solid molecular biology understanding
  • Experience developing and evaluating computational algorithms, statistical methods, or predictive models
  • Proficiency building reproducible workflows using Nextflow or comparable tools
  • Strong foundation in statistics, experimental design, and scientific result interpretation
  • Demonstrated ability to independently investigate scientific problems and learn unfamiliar domains

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