Senior Bioinformatics Scientist Job at Veracyte, South San Francisco, CA

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  • Veracyte
  • South San Francisco, CA

Job Description

Veracyte seeks a Senior Bioinformatics Scientist to lead the design and development of next-generation minimal residual disease tests. The role focuses on NGS-based oncology assay development, analytical validation, and cross-functional collaboration to deliver clinically actionable diagnostics under CAP/CLIA quality systems.

Responsibilities

  • Contribute to bioinformatics strategy for MRD assay design, optimization, and lifecycle management
  • Design and execute analytical studies evaluating assay performance and limit of detection
  • Develop, validate, and maintain scalable production bioinformatics pipelines for MRD analysis
  • Lead benchmarking and optimization of computational methods including error modeling and longitudinal tracking
  • Partner with molecular biology, QA/RA, clinical, and software engineering teams on assay alignment

Requirements

  • Extensive experience with NGS-based oncology assays and assay development
  • Deep expertise in circulating tumor DNA biology and cancer genomics
  • Proven track record of analytical assay development under design control frameworks
  • Strong knowledge of variant detection, error suppression, and computational method optimization
  • Familiarity with regulatory standards including CAP/CLIA, FDA, and IVDR compliance
  • Experience with production-ready bioinformatics pipeline development and validation

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